发明名称 |
PROCESS FOR THE PREPARATION OF CEFUROXIME AXETIL IN AN AMORPHOUS FORM |
摘要 |
<p>A process for preparing cefuroxime axetil in substantially amorphous form comprises forming a mixture of crystalline cefuroxime axetil and at least one pharmaceutically acceptable excipient, and subjecting the mixture to milling for a period of time sufficient to convert the crystalline cefuroxime axetil to substantially amorphous form, i.e., the crystallinity is less than 5%. The amorphous cefuroxime axetil has a chemical purity of at least 95%. Desirably, the particles of the milled material are reduced to a size of less than 2 mu m. The amorphous cefuroxime axetil prepared by this method may consist of R isomer, S isomer, or a racemic mixture of the R and S isomers.</p> |
申请公布号 |
EP1087979(A1) |
申请公布日期 |
2001.04.04 |
申请号 |
EP19990900591 |
申请日期 |
1999.01.27 |
申请人 |
RANBAXY LABORATORIES, LTD. |
发明人 |
SOMANI, JITENDRA, KRISHAN;SETHI, SANJEEV;TYAGI, OM, DUTT |
分类号 |
C07D501/00;C07D501/02;C07D501/12;(IPC1-7):C07D501/12 |
主分类号 |
C07D501/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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