| 摘要 |
organic chemistry, pharmacy. SUBSTANCE: invention describes novel substituted chromanylsulfonyl(thio)ureas of the formula (I) where R(1) means hydrogen atom, alkyl with 1- 4 C-atoms, alkoxyl with 1-4 C-atoms; R(2a), R(2b), R(2c) and R(2e) mean hydrogen atom; R(3) means hydrogen atom or alkyl with 1, 2, 3 or 4 C- -atoms; Q means (CH2)n where n = 1 or 2; Z means sulfur or oxygen atom; A means unsubstituted phenyl or phenyl substituted with up to three similar or different substituents taken among the group including halogen atom, alkyl with 1 or 2 C-atoms, alkoxyl with 1 or 2 C-atoms; or A means residue of saturated or unsaturated lactam of the formula (a) where B means alkenylene or alkylene with 3, 4, 5 or 6 C-atoms that is unsubstituted or substituted with up to three similar or different alkyl groups with 1, 2, 3 or 4 C-atoms; or A means residue of bicyclic system of the formulas (b) , (c) , (d) and (f) and their physiologically acceptable salts. New compounds are valuable medicinal agents and can be used for treatment of patients with disorders of heart rhythm and prevention of sudden death as result of heart stop caused by arrhythmia. They can be used as antiarrhythmic agents for treatment of cardiac insufficiency and cardiac activity fall at shock effects. Invention describes also method of synthesis of these compounds and pharmaceutical composition based on compounds of the formula (I). EFFECT: new compounds indicated above, improved method of synthesis, valuable medicinal properties. 17 cl, 27 ex |
