| 摘要 |
PROBLEM TO BE SOLVED: To provide a technique for enantioselectively and diastereoselectively producing an optically activeβ-aminoalcohol having an anti-configuration for synthetic intermediates of medicines and agrochemicals in a high yield by using a racemicα-aminoketone as a starting material. SOLUTION: This method for producing an optically activeβ-aminoalcohol having an anti-configuration expressed by general formula (2) Ra-C*H(OH)- C*(NHCOORb)-Rc (Ra to Rc are each the same or different and an alkyl, an alkenyl, a cycloalkyl, an aralkyl or an aryl; C* expresses an optically active carbon) is to react a racemicα-amino ketone expressed by general formula (1) Ra-CO-CH(NHCOORb)-Rc (Ra to Rc express each the same meaning as described above) with hydrogen or a hydrogen donating compound in the presence of an optically active transition metal compound and a base. |
