2-PHENYLIMINOTHIAZOLINE DERIVATIVES AND SALTS THEREOF AND PRODUCTION THEREOF

摘要

PURPOSE: A process of preparing 2-phenyliminothiazoline derivatives and salts thereof by reacting isothiocyanate derivatives and phenylamine in an inactive organic solvent and then reacting the obtained phenylthiourea derivatives with gamma-halo-beta-ketoanilide derivatives in the presence of an inactive organic solvent is provided. Whereby, the compounds are useful as an agricultural germicide. CONSTITUTION: 2-phenyliminothiazoline derivatives of formula(I-a) show a fungicidal activity, in particular against rice blast disease. In formula, R1 and R2 are each alkyl expressed by H, methyl, ethyl, propyl, butyl, pentyl or hexyl, halo expressed by fluoro, chloro or bromo, alkoxy expressed by methoxy, ethoxy, propoxy, isopropoxy, butyl, isobutoxy or sec-butoxy, alkoxycarbonyl expressed by cyano, nitro, trifluoromethyl, trifluoromethoxy, methylthio, phenyl, phenoxy, methoxycarbonyl, ethoxycaronyl, propoxycarbonyl or isopropoxycarbonyl; R3 is alkyl expressed by H, methyl, ethyl, propyl, isopropyl, cyclopropyl, butyl, pentyl, cyclopentyl, hexyl, cyclohexyl or aryl, or cycloalkyl; and X is Cl or Br.