| 摘要 |
The present invention provides methods for inhibiting or preventing hyperplastic intimal growth by intravascular administration of a composition comprising heparin, or a derivative thereof in conjunction with at least one electric pulse having sufficient strength and duration to cause electroporation of the cells lining the blood vessel. Such treatment inhibits or prevents hyperplastic intimal growth in vessels, such as arteries, as compared with a non-electroporated vessel to which the heparin, or derivative thereof, is administered. In another aspect, the present invention provides methods for electroporation-enhanced local delivery of heparin to cells lining an artery in a subject by directly applying at least one electric pulse to the interior surface of the artery in conjunction with local application of a composition comprising heparin, or a derivative thereof, said electric pulse having sufficient strength and duration to locally deliver the heparin to the artery so as to decrease hyperplastic intimal growth compared with that in an untreated region of the artery. A unique intravascular porous balloon electroporation catheter can be used to apply the composition directly to the arterial wall.
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