| 摘要 |
A once daily sustained release pharmaceutical compositions of Trimetazidine or a pharmaceutically acceptable salt(s), polymorph(s), solvate(s), hydrate(s), enantiomer(s) thereof using dual retard release technique. These compositions comprise a core comprising trimetazidine or a pharmaceutically acceptable salt(s), polymorph(s), solvate(s), hydrate(s), enantiomer(s) thereof, one or more sustained release polymer(s) in a matrix and one ore more pharmaceutically acceptable excipient(s), wherein the core is further coated with a functional coating. The compositions of the invention have reduced fluctuations of peak- valley plasma concentration as compared to 35mg twice daily modified release formulation. |
