发明名称 |
Anti-tumor fusion protein |
摘要 |
A fusion protein comprising domain (a) which is a functional fragment of hTRAIL protein sequence, which fragment begins with an amino acid at a position not lower than hTRAIL95, or a homolog of said functional fragment having at least 70% sequence identity, preferably 85% identity and ending with the amino acid hTRAIL281; and at least one domain (b) which is a sequence of a cytolytic effector peptide forming pores in the cell membrane, wherein the sequence of domain (b) is attached at the C-terminus or N-terminus of domain (a). The fusion protein can be used for the treatment of cancer diseases. |
申请公布号 |
PL223487(B1) |
申请公布日期 |
2016.10.31 |
申请号 |
PL20110397595 |
申请日期 |
2011.12.28 |
申请人 |
ADAMED SPÓŁKA Z OGRANICZONĄ ODPOWIEDZIALNOŚCIĄ |
发明人 |
PIECZYKOLAN JERZY SZCZEPAN;PAWLAK SEBASTIAN DOMINIK;ŻEREK BARTŁOMIEJ;RÓZGA PIOTR KAMIL |
分类号 |
C07K14/705;A61P35/00;C12N15/62 |
主分类号 |
C07K14/705 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|