| 摘要 |
<p>A bacteriophage preparation is provided comprising a bacteriophage which is adapted to enter a eukaryotic cell and/or a eukaryotic cellular compartment, which bacteriophage is lytic towards at least one strain of pathogenic bacteria which may infect said cell or compartment, which bacteriophage is fused to, or linked to, or is adapted to express an annihilation moiety, which annihilation moiety is adapted when in the presence of at least one specific pathogen to cause or stimulate the death or inactivation of said cell; such that said bacteriophage preparation is capable of causing or stimulating the death or inactivation of cells which are infected with said pathogen. The invention further comprehends a pharmaceutical composition comprising such a bacteriophage preparation, formulated for administration to a patient in need thereof; method for producing the death or inactivation of a cell infected by a pathogen through the administration of such a bacteriophage preparation thereto; and the use of such a bacteriophage preparation in the manufacture of such a pharmaceutical composition, optionally for use in the treatment and/or the prophylaxis of a disease which is mediated or characterised by intracellular infection by a pathogen, including in particular tuberculosis, AIDS, HIV infection, and malaria.</p> |
