NEW MEDIUM-MEMBERED RING AMINE HAVING PLANE ASYMMETRY AND METHOD FOR PRODUCING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a new optically active amine having a 9-membered ring having a plane asymmetry stable at room temperature as the sole asymmetry, completely transferring the plane asymmetry of the amine to the central asymmetry of a rearranged product by the Cope rearrangement and the aza-[2, 3]- Witting rearrangement using the optically active amine 1 as a substrate, useful as a chiral synthon and usable as an asymmetric assisting group, an asymmetric ligand and a chiral synthon. SOLUTION: The amine having a 9-membered ring is expressed by the formula [R1is H, methyl or ethyl; R2is H, methyl or ethyl; and R3is tosyl, acetyl, Boc, benzyl, methylacetatic acid group or H). COPYRIGHT: (C)2003,JPO