| 摘要 |
PROBLEM TO BE SOLVED: To provide a new optically active (R)-1-(4-trifluoromethylphenyl) ethylamine useful as an important intermediate for medicines and agrochemicals. SOLUTION: This optically active (R)-1-(4-trifluoromethylphenyl) ethylamine can be synthesized in a high optical purity and in a good yield by subjecting 4'-(trifluoromethyl)acetophenone and optically active (R)-1-phenylethylamine to a dehydrative condensation under an acidic condition, asymmetrically reducing the obtained optically active imine into the optically active secondary amine, deriving the secondary amine into its phthalate or benzene sulfonate which are the organic acid salts, recrystallizing and purifying the organic acid salt, hydrolyzing the purified organic acid salt to produce the optically active (R)-1-(4- trifluoromethylphenyl)ethylamine phthalate or benzene sulfonate as the organic acid salt, and then neutralizing the product. COPYRIGHT: (C)2004,JPO |
