发明名称 |
Methods and compositions for inhibiting endothelial cell and fibrinogen mediated inflammation |
摘要 |
The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endothelial cells in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Also described are therapeutic compositions containing an ICAM-1 homolog capable of binding to fibrinogen in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Methods of inhibiting endothelial cell and fibrinogen mediated inflammation within a patient by administering a homolog of this invention are also contemplated.
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申请公布号 |
US6676940(B2) |
申请公布日期 |
2004.01.13 |
申请号 |
US20010912740 |
申请日期 |
2001.07.24 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
ALTIERI DARIO C.;LANGUINO LUCIA R.;THORNTON GEORGE B. |
分类号 |
A61K38/00;C07K14/705;C07K14/75;C07K16/28;C07K16/36;(IPC1-7):A61K39/395;G01N33/567 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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