Peptides derived from complement peptide C3a sequence and antiallergic compositions comprising them

摘要

Peptides corresponding partially or entirely to positions 50-77 of the sequence of the complement-derived peptide C3a and analogs thereof are capable of inhibiting IgE-mediated triggering and/or the FcepsilonRI-induced secretory response of mucosal mast cells. These peptides are useful for prevention and/or treatment of allergic disorders caused by IgE mediated (Type I) hypersensitivity where mucosal-type mast cells are involved, such as hay fever, asthma, some cases of urticaria or allergic conjunctivitis.