| 摘要 |
Method and system for diagnosing and treating thalamocortical dysrhythmia. Thalamocortical dysrhythmia occurs when unbalanced neural activity occurs due to the rise of low frequency (approximately 4-8 Hz) and high frequency (approximately 20-50 Hz) neuronal oscillation activity simultaneously within awake individuals. The underlying mechanism that causes thalamocortical dysrhythmia is abnormal input into thalamic cells, which causes a low-frequency shift, increased amplitude, and increased frequency correlation of neuronal oscillation at the cortical and thalamic levels. The present invention measures the neuronal activity at the cortical level, filters these measurements, and performs a Fourier transform to transfer neuronal oscillation data into the frequency domain. The present invention then selects at least one reference baseline based on the characteristics of control subjects that do not have thalamocortical dysrhythmia and/or patients that have thalamocortical dysrhythmia. The present invention determines the amplitude, frequency, and correlation deviations of the measured neuronal oscillations relative to the selected baselines and then determines whether an individual has thalamocortical dysrhythmia based on the deviations from the selected baselines. The present invention is thereby able to diagnose individuals as having or not having thalamocortical dysrhythmia, as well as to prescribe treatment for thalamocortical dysrhythmia based on the diagnosis and underlying amplitude, frequency and correlation deviation measurements.
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