发明名称 |
Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists |
摘要 |
The present invention provides phenyl urea and phenyl thiourea derivatives which are non-peptide antagonists of human orexin receptors, in particular orexin-1 receptors, of formula (I)in which:Z represents oxygen or sulfur; and R<1 >to R<7 >represent various substituent groups; and pharmaceutically acceptable salts thereof. In particular, these compounds are of potential use in the treatment of obesity including obesity observed in Type 2(non-insulin-dependent) diabetes patients and/or sleep disorders.
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申请公布号 |
US6699879(B1) |
申请公布日期 |
2004.03.02 |
申请号 |
US20020913236 |
申请日期 |
2002.04.29 |
申请人 |
SMITHKLINE BEECHAM P.L.C. |
发明人 |
COULTON STEVEN;JOHNS AMANDA;PORTER RODERICK ALAN |
分类号 |
A61K31/47;A61K31/4709;A61P3/04;A61P3/10;A61P5/02;A61P5/10;A61P25/00;A61P25/18;A61P25/20;A61P25/24;A61P43/00;C07D215/46;C07D401/12;C07D413/12;C07D417/12;(IPC1-7):A61K31/47;C07D215/38;C07D215/18 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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