发明名称 |
PROCESS FOR THE PREPARATION OF 2,4-DIDEOXYHEXOSES AND 2,4,6-TRIDEOXYHEXOSES |
摘要 |
The invention relates to a process for the preparation of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose from a substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one alpha-hydrogen atom and a substituted or unsubstituted aldehyde in the presence of an aldolase and water, the reaction between the substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one alpha-hydrogen atom and the substituted or unsubstituted aldehyde being carried out at a carbonyl concentration of at most 6 moles/l of reaction mixture and the final concentration of the 2,4-dideoxyhexose or the 2,4,6-trideoxyhexose being at least 2 mass % of the reaction mixture. The invention also relates to the use of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose obtained by means of a process according to the invention in the preparation of a medicine, particularly in the preparation of a statine. |
申请公布号 |
EP1404844(A2) |
申请公布日期 |
2004.04.07 |
申请号 |
EP20020746200 |
申请日期 |
2002.07.09 |
申请人 |
DSM IP ASSETS B.V. |
发明人 |
KIERKELS, JOANNES, GERARDUS, THEODORUS;MINK, DANIEL;PANKE, SVEN;LOMMEN, FRANCISCUS, ALPHONS, MARIE;HEEMSKERK, DENNIS |
分类号 |
C12N1/21;C12N9/88;C12N15/60;C12P19/02 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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