发明名称 |
METHOD FOR IDENTIFYING ACTIVE ANTI-APOPTOSIS COMPOUNDS |
摘要 |
Method for identifying anti-apoptotic compounds (A) by: (i) culturing cells that express both integrin-associated protein (IAP) and the alpha vbeta 3 integrin (In1); (ii) allowing the cells to express apoptosis-inducing compounds (and/or adding these compounds); (iii) adding the test compound and (iv) measuring the rate of apoptosis. Independent claims are also included for the following: (1) (A) identified this way, optionally able to bind to at least one of IAP, In and thrombospondin-1 (TSP-1) so that simultaneous binding of IAP and In to TSP-1 is prevented; and (2) pharmaceutical composition containing (A). ACTIVITY : Cardiovascular; anti-arteriosclerosis. MECHANISM OF ACTION : Inhibition of apoptosis in vascular endothelial cells by preventing interaction between thrombospondin-1 (TSP-1) and cell-surface IAP and In1 (this interaction is the cause of spontaneous apoptosis in endothelial cells grown under static conditions). |
申请公布号 |
EP1226433(B1) |
申请公布日期 |
2004.04.07 |
申请号 |
EP20000977466 |
申请日期 |
2000.11.02 |
申请人 |
CYTOTOOLS GMBH |
发明人 |
FREYBERG, MARK, ANDRE;FRIEDL, PETER;KAISER, DIRK |
分类号 |
A61K39/395;A61K45/00;A61P9/00;A61P9/10;A61P9/14;C07K16/18;C12Q1/02;G01N33/15;G01N33/50;G01N33/566 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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