PHARMACEUTICAL COMPOSITION FOR PROPHYLAXIS AND TREATMENT OF PAPILLOMAVIRUS-DERIVED DISEASES COMPRISING PAPILLOMAVIRUS ANTIGEN PROTEIN AND CpG-OLIGODEOXYNUCLEOTIDE

摘要

PURPOSE: Provided is a pharmaceutical composition for prophylaxis and treatment of Papillomavirus-derived diseases comprising Papillomavirus antigen protein and CpG-oligodeoxynucleotide. Therefore, it has anti-cancer activity in the animal model, shows CTL reaction, and induces the generation of IFN-γ in CD4+T lymphocyte and CD8+ T lymphocyte. CONSTITUTION: A pharmaceutical composition for prophylaxis and treatment of Papillomavirus-derived diseases is characterized by comprising immunologically effective amount of Papillomavirus E7 antigenic protein and CpG-oligodeoxynucleotide of 5'-TCCATGACGTTCCTGACGTT-3'.