发明名称 |
Stabilized azithromycin compositions |
摘要 |
Compositions and methods of stabilizing azithromycin compositions are described. Stabilized azithromycin compositions comprise an intimate admixture of azithromycin and a stabilizing-effective amount of an antioxidant to improve the resistance of the azithromycin to degradation. Coprecipitation or co-milling of azithromycin and an antioxidant are particularly preferred means of achieving an intimate admixture. Pharmaceutical formulations comprising a stabilized azithromycin composition and methods of making such formulations are also described.
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申请公布号 |
US6764997(B2) |
申请公布日期 |
2004.07.20 |
申请号 |
US20020274097 |
申请日期 |
2002.10.18 |
申请人 |
TEVA PHARMA |
发明人 |
TENENGAUZER RUTH;SCHWARZ JOSEPH;HRAKOVSKY JULIA;LESSEN TANIA;KHONDO LEV;MATHIVANAN MATHI;SINGER CLAUDE;PESACHOVICH MICHAEL |
分类号 |
A61K9/00;A61K9/14;A61K9/16;A61K9/20;A61K31/353;A61K31/375;A61K31/70;A61K31/7048;A61K31/7052;A61K47/10;(IPC1-7):A61K31/70 |
主分类号 |
A61K9/00 |
代理机构 |
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地址 |
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