GENE AND PROTEIN OF VIRULENCE AND THEIR USING

摘要

FIELD: biotechnology, medicine. ^ SUBSTANCE: invention can be used for treatment and prophylaxis of diseases associated with streptococcus infection or microorganism Gr+. Invention relates to peptide that is encoded by S. pyogenes nucleic acid with nucleotide sequence taken among the group of sequences given in the materials of claim. Also, invention involves peptide-related molecule showing at least 80% similarity degree at amino acid or nucleotide level. Both peptide and polynucleotide encoding it can be used as a medicinal agent for treatment or prophylaxis of diseases caused by streptococcus or microorganism Gr+. Invention relates vaccine used as mentioned above and also antibody able to bind peptide. Identification of genes encoding products associated with virulence allows producing attenuated microorganisms useful for preparing vaccines for therapeutic application. ^ EFFECT: valuable biological and medicinal properties of gene and protein. ^ 14 cl, 25 ex