发明名称 |
Sigma-2 receptor ligand drug conjugates as antitumor compounds, methods of synthesis and uses thereof |
摘要 |
Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described. At least one described molecular species exhibits an IC |
申请公布号 |
AU2015240775(A1) |
申请公布日期 |
2016.10.20 |
申请号 |
AU20150240775 |
申请日期 |
2015.04.01 |
申请人 |
Washington University |
发明人 |
Hawkins, William;Mach, Robert;Spitzer, Dirk;Vangveravong, Suwanna;Van Tine, Brian |
分类号 |
C07D403/14;A61P35/00 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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