| 摘要 |
<p>The invention provides a combined vaccine, comprising Mycoplasma hyopneumoniae and at least one viral antigen which advantageously provides immunity from infection after a single administration. The composition comprises also an adjuvant mixture, which, in combination, provides immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the adjuvant mixture comprises an acrylic acid polymer, most preferably Carbopol, and a mixture of a metabolizable oil such as one or more unsaturated terpene hydrocarbons, preferably squalene or squalane, and a polyoxyethylene-polyoxypropylene block copolymer such as Pluronic. The vaccine composition may optionally include a preservative, preferably thimerosol and/or EDTA.</p> |
