发明名称 |
HIV-encoded chemoattractant |
摘要 |
The combination of HIV proteins Tat and Nef is chemotactic for CD4+ cells. Utilizing the capacity of Tat and Nef to modulate CD4+ cell trafficking and infiltration, the invention provides various treatment modes for individuals infected with HIV. The invention further provides treatment modes for other localized diseases by controlling CD4+ cell trafficking and infiltration. In particular, the invention provides methodology for promoting CD4+ cell chemotaxis to a localized site of infection as a means of augmenting the efficacy of extant chemotherapeutic methods. The invention further provides methodology for diverting CD4+ cell infiltration from a localized site where the presence of CD4+ cells is detrimental to the clinical outcome, by providing a composition comprising Tat and Nef at a distinct site, such as blood, within the individual where the accumulation of CD4+ cells is less detrimental.
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申请公布号 |
US6878685(B2) |
申请公布日期 |
2005.04.12 |
申请号 |
US20020274361 |
申请日期 |
2002.10.21 |
申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
SOLL DAVID R.;SHUTT DAMON |
分类号 |
A61K38/16;A61K38/20;A61K39/39;A61P31/18;C07K14/16;(IPC1-7):A61K38/01;A61K38/19;A61K51/00;A61K51/08;A61K45/08;A61K39/21 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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