MODIFICATION OF MICROORGANISM TRANSGLUTAMINASE,申请号RU20030104512-传众专利搜索

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发明名称	MODIFICATION OF MICROORGANISM TRANSGLUTAMINASE
摘要	FIELD: biotechnology, in particular method for construction and production of mutant transglutaminases (MTG). ^ SUBSTANCE: invention relates to method for construction and production of mutant transglutaminases based on space structure of transglutaminase obtained from Streptoverticillium mobaraense, as well as to mutant MTG obtained by said method. Also disclosed are method for MTG modification based on space structure and modified transglutaminase with enhanced reactivity relative to substrate. Method of present invention makes it possible to predict MTG binding site to substrate on the base of space structure that is determined by MNG crystal X-ray analysis, and to design mutant transglutaminases by replacement, insertion or deletion of amino acid residues disposed on transglutaminase substrate-binding site. ^ EFFECT: new method for production and modification of mutant transglutaminases. ^ 6 cl, 60 dwg, 5 ex
申请公布号	RU2260051(C2)	申请公布日期	2005.09.10
申请号	RU20030104512	申请日期	2001.08.15
申请人		发明人	KASIVAGI TATSUKI;SIMBA NOBUKHISA;ISIKAVA KOKHKI;SUZUKI EI-ITIRO;KHIRAJAMA KAZUO;JOKOJAMA KEJITI
分类号	C07K14/195;C12N1/15;C12N1/19;C12N1/21;C12N9/10;C12N15/10;C12N15/54;C12N15/63;C12P21/00;C12R1/625	主分类号	C07K14/195
代理机构		代理人
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