3-SUBSTITUTED 4-(PHENYL-N-ALKYL)-PIPERIDINES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHODS FOR TREATMENT

摘要

FIELD: organic chemistry, medicine, neurology, pharmacy. ^ SUBSTANCE: invention relates to 3-substituted 4-(phenyl-N-alkyl)piperidines of the general formula (1): ^ wherein R1 represents -OSO2CF3, -OSO2CH3, -SOR3, -SO2R3, -COR3; R2 represents (C1-C4)-alkyl, allyl, -CH2CH2OCH3, -CH2CH2CH2F, -CH2CF3, 3,3,3-trifluoropropyl, 4,4,4,-trifluorobutyl group; R3 represents (C1-C3)-alkyl, -CF3, and their pharmaceutically acceptable salts also. Also, invention discloses pharmaceutical compositions of abovementioned compounds and methods wherein abovementioned compounds are used in treatment of the central nervous system disturbances. ^ EFFECT: improved methods for treatment, valuable medicinal properties of compounds and compositions. ^ 31 cl, 47 ex