PHARMACEUTICAL COMPOSITIONS COMPRISING FENTANYL FOR INTRANASAL DELIVERY.

摘要

This invention provides a composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal, which comprises an aqueous solution of (i) fentanyl or a pharmaceutically acceptable salt thereof and (ii) a pharmaceutically acceptable additive selected from (a) a pectin and (b) a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax)that is from 10 to 80% of- that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose.