发明名称 |
MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME |
摘要 |
The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin- 15 (IL- 15) polypeptide or a functional fragment thereof. The second fusion 5 protein is a second biologically active polypeptide covalently linked to a soluble interleukin 15 receptor alpha (IL-15Ra) polypeptide or a functional fragment thereof In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-1 5Ra domain of the second fusion protein to form a soluble fusion 0 protein complex. The invention further provides methods for making and using the complexes of the invention. |
申请公布号 |
AU2017201056(A1) |
申请公布日期 |
2017.03.02 |
申请号 |
AU20170201056 |
申请日期 |
2017.02.16 |
申请人 |
Altor Bioscience Corporation |
发明人 |
Wong, Hing C.;Rhode, Peter;Liu, Bai;Zhu, Xiaoyun;Han, Kai-Ping |
分类号 |
C07K14/075;A61K38/17;A61P35/00;C07K14/54;C07K19/00;C12N15/62 |
主分类号 |
C07K14/075 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|