| 发明名称 |
Protective vaccine based on <i>Staphylococcus aureus </i>SA2451 protein |
| 摘要 |
The present invention relates to methods of inducing an immune response to Staphylococcus comprising administering a composition comprising an SA2451-related polypeptide from Staphylococcus aureus as well as derivatives or fragments thereof. The present invention also encompasses methods of treating and/or reducing the likelihood of a Staphylococcus infection by administering a composition comprising an SA2451-related polypeptide or an antibody that specifically binds to an SA2451 polypeptide, derivative or fragments thereof. Compositions administered in the methods of the invention can include one or more additional antigens. Compositions used to practice the methods of the invention are also encompassed. |
| 申请公布号 |
US9527892(B2) |
申请公布日期 |
2016.12.27 |
| 申请号 |
US201214354948 |
申请日期 |
2012.10.26 |
| 申请人 |
Merck Sharp & Dohme Corp. |
发明人 |
McNeely Tessie;Montgomery Donna Lorraine;Cope Leslie;Joshi Amita;Pancari Gregory P.;Fan Hongxia |
| 分类号 |
A61K39/00;A61K39/38;A61K39/02;A61K39/085;A61K45/00;A61K47/00;A01N63/00;C07K14/31;A61K38/00;A61K39/39;A61K8/99 |
主分类号 |
A61K39/00 |
| 代理机构 |
|
代理人 |
Wu Henry P.;Fuentes Gloria M. |
| 主权项 |
1. A method of inducing an immune response in a patient against Staphylococcus aureus infection comprising administering an immunologically effective amount of the polypeptide of SEQ ID NO: 1, a pharmaceutically acceptable carrier and an adjuvant. |
| 地址 |
Rahway NJ US |
