Sulfonamide derivative and use thereof

摘要

Provided is a compound having an AMPA receptor function enhancing action, and useful as a prophylactic or therapeutic drug for depression, Alzheimer's disease, schizophrenia, attention deficit hyperactivity disorder (ADHD) and the like. A compound represented by the formula (I):;
wherein each symbol is as defined in the present specification,

or a salt thereof.

主权项

1. A compound represented by the formula (I) wherein
R1 is a C1-6 alkyl group optionally substituted by 1 to 3 substituent(s) selected from a halogen atom and a C1-3 alkoxy group; a C3-6 cycloalkyl group; or an amino group substituted by a C1-6 alkyl group,
R2 and R3 are hydrogen atoms,X is —O—,ring A is selected from C3-6 cycloalkane; a tetrahydrofuran ring; a tetrahydropyran ring; a piperidine ring; a tetrahydrothiopyran ring; and a 8-oxabicyclo[3.2.1]octane ring, each optionally substituted by 1 to 3 substituents selected from (1) 1 to 3 halogen atoms; (2) a C1-6 alkyl group optionally substituted by one phenyl group; (3) a carbamoyl group substituted by a C1-6 alkyl group; (4) a C1-6 alkyl-carbonyl group; (5) a C1-6 alkoxy-carbonyl group; (6) an oxo group; (7) a hydroxyl group; and (8) a C1-6 alkylsulfonyl group, and
ring B is selected from a benzene ring; C3-6 cycloalkane; a dihydroindene ring; a naphthalene ring; a pyridine ring; a chromene ring; an indole ring; and a benzothiazole ring, each optionally having 1 to 3 substituent(s) selected from (1) a halogen atom; (2) a cyano group; (3) a C1-6 alkyl group optionally substituted by 1 to 3 substituents selected from a halogen atom and a cyano group; (4) a hydroxyl group optionally substituted by a C1-6 alkyl group optionally substituted by 1 to 3 halogen atoms or a phenyl group; (5) an amino group optionally substituted by 1 or 2 substituents selected from a C1-6 alkyl group, a C1-6 alkyl-carbonyl and a phenyl group; (6) a C3-6 cycloalkyl group; (7) a tricyclo[3.3.1.1.3.7]decyl group; (8) phenyl optionally substituted by 1 to 3 substituents selected from a halogen atom and a cyano group; (9) pyridyl optionally substituted by 1 to 3 substituents selected from a halogen atom, a cyano group and a C1-6 alkyl group optionally substituted by 1 to 3 halogen atoms; (10) pyrazolyl optionally substituted by 1 to 3 substituents selected from a halogen atom, a cyano group, a C1-6 alkyl group optionally substituted by 1 to 3 halogen atoms and a C1-6 alkoxy group optionally substituted by 1 to 3 halogen atoms; (11) imidazolyl optionally substituted by a C1-6 alkyl group; (12) thienyl optionally substituted by a cyano group; (13) pyrimidinyl optionally substituted by 1 to 3 substituents selected from a halogen atom and a cyano group; (14) isoxazolyl substituted by a C1-6 alkyl group; (15) oxazolyl optionally substituted by a C1-6 alkyl group optionally substituted by 1 to 3 halogen atoms; (16) thiazolyl optionally substituted by 1 to 3 substituents selected from a halogen atom and a C1-6alkyl group optionally substituted by 1 to 3 halogen atoms; (17) piperidyl optionally substituted by 1 to 3 substituents selected from a C1-6 alkyl group optionally substituted by 1 to 3 halogen atoms and an oxo group; (18) pyrrolidyl optionally substituted by 1 to 3 substituents selected from a halogen atom and an oxo group; (19) dihydropyridyl optionally substituted by 1 to 3 substituents selected from a C1-6 alkyl group and an oxo group; (20) tetrahydropyridazinyl optionally substituted by 1 to 3 substituents selected from a C1-6 alkyl group and an oxo group; (21) oxetanyl; (22) morpholinyl; (23) tetrahydropyranyl; (24) a sulfanyl group optionally substituted by a C1-6 alkyl group substituted by 1 to 3 halogen atoms; (25) a C1-6 alkyl-carbonyl group; (26) a C1-6 alkoxy-carbonyl group; and (27) an oxo group, or a salt thereof.