Mixed ligand gold(III) complexes and methods thereof

摘要

Gold(III) complexes having mixed ligands as anticancer agents. The atom is coordinated by bidentate ligands having diamino functional groups: a diaminocyclohexane ligand and an ethylenediamine ligand. These complexes can exist in both cis- and trans-configurations. Also described are pharmaceutical compositions incorporating the gold(III) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis.

主权项

1. A gold(III) complex having Formula A: or a pharmaceutically acceptable salt, ester, solvate or prodrug thereof; wherein:
the complex has a cis- or trans-configuration;1-6 each represents a carbon atom;R1-R8 are each independently selected from the group consisting of a hydrogen atom; a linear or branched, substituted or unsubstituted C1-C8 alkyl group; and a substituted or unsubstituted C6-C8 aryl group; andR9-R20 are each independently selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group a N-monosubstituted amino group, a N,N-disubstituted amino group, a substituted or unsubstituted C1-C8 alkyl group, a substituted or unsubstituted C1-C8 alkoxy group a substituted or unsubstituted C3-C8 cycloalkyl group, and a substituted or unsubstituted C6-C8 aryl group.