5-HYDROXY-6-AMINO-METHLYBENZOFURAN DERIVATIVES AND PREPARATION THEREOF

摘要

1433459 5-Hydroxy-6-aminomethylbenzofuran derivatives VSES NI KHIMIKOFARMATSEVTICHE INST IM S ORDZHONIKIDZE and VINNIT MEDITSIN INST 16 May 1974 [18 May 1973] 21916/74 Heading C2C Novel compounds of Formula I in which R is an alkyl group, R1 is an alkyl or aryl group, R2 is an alkyl group, R3 is an alkyl group or R2 and R3 form, together with the nitrogen atom to which they are attached, a heterocyclic ring containing one or two heteroatoms and, optionally, an alkyl substituent, and X is halogen, and physiologically acceptable acid addition salts thereof and prepared by reacting a compound of formula with an amine R2R3NH and formaldehyde or a bisamino methane (R2R3N) 2 CH 2 . Pharmaceutical compositions having local anaesthetic activity being in conventional forms for topical and subcutaneous application comprises an above novel compound and a carrier or diluent.