| 发明名称 |
ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) |
| 摘要 |
PROBLEM TO BE SOLVED: To provide antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (PCSK9) and their use as pharmaceuticals.SOLUTION: An isolated monoclonal antibody binds to at least one specific residue of a specific sequence when binding to PCSK9, and blocks the binding of PCSK9 to LDLR.SELECTED DRAWING: Figure 26 |
| 申请公布号 |
JP2016182114(A) |
申请公布日期 |
2016.10.20 |
| 申请号 |
JP20160053430 |
申请日期 |
2016.03.17 |
| 申请人 |
AMGEN |
发明人 |
JACKSON SIMON MARK;NIGEL PELHAM CLINTON WALKER;DEREK EVAN PIPER;SHAN BEI;SHEN WENYAN;CHAN JOYCE CHI YEE;CHADWICK TERENCE KING;RANDAL ROBERT KETCHEM;MEHLIN CHRISTOPHER;TERESA ARAZAS CARABEO;CAO QIONG |
| 分类号 |
C12N15/09;A61K31/22;A61K31/336;A61K31/366;A61K31/40;A61K31/404;A61K31/4418;A61K31/47;A61K31/505;A61K39/395;A61K45/00;A61P3/06;A61P43/00;C07K16/40;C12P21/08 |
主分类号 |
C12N15/09 |
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