| 摘要 |
1508170 2-Formylcyclopentaneheptanoic acid derivatives PFIZER Inc 10 Dec 1975 [11 Dec 1974] 29061/77 Divided out of 1508168 Heading C2C The invention comprises 2-formylcyclopentaneheptanoic acid derivatives of the formula wherein R<SP>2</SP> and R<SP>3</SP> each are C 1-10 alkyl, C 7-9 aralkyl, or 1- or 2-naphthyl or phenyl optionally substituted by Cl, Br, F, C 1-6 alkyl, C 1-6 alkoxy or phenyl and their preparation by oxidizing the corresponding 2-hydroxymethylcyclopentaneheptanoic acid derivatives. Methyl 7 - [2# - hydroxymethyl - 5α - acetoxyla-cyclopentyl]heptanoate is prepared by the hydrogenation of methyl 7-[2#-benzyloxymethyl- 5α - acetoxy - 1α - cyclopentyl] - cis - 5 - heptenoate, resulting from the acetylation of methyl 7 - [2# - benzyloxymethyl - 5α - hydroxy - 1α- cyclopentyl] - cis - 5 - heptenoate, obtained by esterifying 7 - [2# - benzyloxymethyl - 5α- hydroxy - 1α - cyclopentyl] - cis - 5 - heptenoic acid which is made by reacting (4-carboxybutyl)- triphenylphosphonium bromide with 4#-benzyloxymethyl - 3,3a#,4,5,6,6a# - hexahydro - 2H- cyclopenta[b]furan-2-ol. |
