发明名称 |
SETT ATT FRAMSTELLA NYA 5-KARBOXIALKYL-2-IMINOBARBITUR- OCH 2-TIOXOBARBITURSYRADERIVAT |
摘要 |
5-Carboxyalkyl-2-iminobarbituric and 5-carboxyalkyl-2-thioxobarbituric acids and derivatives thereof are prepared either by condensation of a triester of a tricarboxylic acid with a thio or imino diamide to yield an ester which is saponified, the desired compound being obtained by liberation with a mineral acid from an ammoniacal medium containing the saponified ester. Alternatively, free tricarboxylic acids may be substituted for the triesters. The compounds described herein have evidenced a therapeutic effect in animals having transplanted tumors, and have inhibited tumor growth and lengthened the life of animals and humans. |
申请公布号 |
SE7601434(A) |
申请公布日期 |
1976.08.18 |
申请号 |
SE19760001434 |
申请日期 |
1976.02.10 |
申请人 |
SPOFA SPOJENE POKNIKY PROZDRAVOTNICKOU VYROBU |
发明人 |
SEMONSKY M;KOTVA R;CERNY A;KREPELKA J;PUJMAN V;VESELA H;ANDRYSEK O |
分类号 |
C07D239/46;C07D239/54;C07D239/545;C07D239/62;C07D239/66;(IPC1-7):C07D239/46 |
主分类号 |
C07D239/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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