发明名称 |
METHODS OF GENERATING BIOACTIVE PEPTIDE-BEARING ANTIBODIES AND COMPOSITIONS COMPRISING THE SAME |
摘要 |
In one aspect, the invention provides an isolated antibody, or antigen-binding fragment thereof, comprising a bioactive peptide amino acid sequence, wherein the bioactive peptide amino acid sequence is an inhibitor of the complement system and is fused to at least one of: (i) the amino terminal region of at least one of: a light chain variable region and/or a heavy chain variable region; or (ii) the carboxy terminal region of at least one of: a light chain constant region and/or a heavy chain constant region, wherein the antibody inhibits complement activation. |
申请公布号 |
EP2968546(A4) |
申请公布日期 |
2016.11.02 |
申请号 |
EP20140764165 |
申请日期 |
2014.03.14 |
申请人 |
OMEROS CORPORATION |
发明人 |
CUMMINGS, W., JASON;GRAY, PATRICK;TJOELKER, LARRY, W.;YABUKI, MUNEHISA |
分类号 |
A61K39/395;C07K14/81;C07K16/40 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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