发明名称 |
A MULTILAYER PHARMACEUTICAL COMPOSITION COMPRISING AN ANTAGONIST IN A FIRST LAYER AND AN AGONIST IN A SECOND LAYER |
摘要 |
The present invention relates to abuse-resistant, sustained-release dosage forms comprising opioids , and provides for sequestering subunits comprising an antagonist and an agonist. The subunit comprise of an antagonist in a first layer and an agonist in a second layer, upon said first layer such that the antagonist is substantially sequestered when administered to a human being in an intact form, such that physical disruption of the dosage form decreases the euphoric effect of the agonist when administered to a person as compared to an immediate release agonist composition. In a preferred embodiment, the agonist is morphine, and the antagonist is naltrexone. Pharmaceutical compositions comprising said subunit are also provided. WO 2009/032270 PCT/US2008/010357 6 ----- -------- 0 0 0.5 1 1.5 2 3 4 6 8 MORPHINE -- WHOLE CRUSHED --------- PLACEBO |
申请公布号 |
AU2014250614(B2) |
申请公布日期 |
2016.11.10 |
申请号 |
AU20140250614 |
申请日期 |
2014.10.14 |
申请人 |
Alpharma Pharmaceuticals, LLC |
发明人 |
Liang, Alfred;Stauffer, Joseph;Jones, James |
分类号 |
A61K9/20;A61K31/135;A61K31/485 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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