| 发明名称 | 5-ALA for detection of brain tumors | ||
| 摘要 | The present disclosure relates to methods for detecting brain tumors and assessing the recurrence of such tumors by administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) and detecting the conversion of 5-ALA to protoporphyrin IX (PPIX) associated with brain-derived microparticles. | ||
| 申请公布号 | US9493810(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201313838895 | 申请日期 | 2013.03.15 |
| 申请人 | PIOMA, INC. | 发明人 | Ezrin Alan M. |
| 分类号 | C12Q1/26;C12Q1/48;C12Q1/527;G01N33/574 | 主分类号 | C12Q1/26 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. A method for detecting a WHO grade III or grade IV brain tumor, wherein the method comprises administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) to a subject; isolating microvesicles from a biological sample from the subject; and detecting the level of conversion of 5-ALA to protoporphyrin IX (PPIX) associated with microvesicles shed from the WHO grade III or grade IV brain tumor in the biological sample from the subject, thereby detecting the WHO grade III or grade IV brain tumor. | ||
| 地址 | Miami FL US | ||