Foldover sensors and methods for making and using them

摘要

The invention disclosed herein includes sensors having three dimensional configurations that allow expansive “360°” sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

主权项

1. An analyte sensor apparatus comprising:
a base substrate comprising a planar sheet of a flexible material, wherein the base substrate is folded to form a fixed bend; a plurality of working electrodes, a plurality of counter electrodes and a plurality of reference electrodes disposed upon a first surface of the base substrate; a plurality of contact pads disposed upon the first surface of the base substrate; a plurality of electrical conduits disposed upon the first surface of the base substrate, wherein the plurality of electrical conduits are adapted to transmit electrical signals between the plurality of working electrodes, the plurality or counter electrodes or the plurality of reference electrodes and the plurality of contact pads; an analyte sensing layer disposed over at least one of the plurality of working electrodes, wherein the analyte sensing layer detectably alters the electrical current at the at least one of the plurality of working electrodes in the presence of an analyte; and an analyte modulating layer disposed over the analyte sensing layer, wherein the analyte modulating layer modulates the diffusion of the analyte therethrough;wherein:
the base substrate comprises the fixed bend so as to form a configuration characterized in that: at least one of the plurality of working electrodes, the plurality of counter electrodes or the plurality of reference electrodes is disposed on a first side of the fixed bend; and at least one of the plurality of working electrodes, the plurality of counter electrodes or the plurality of reference electrodes is disposed on a second side of the fixed bend and the plurality of contact pads are disposed on the first side of the fixed bend.