Carcinostatic or immunostimulant medicaments - contg. propionic acid deriv. precursors of (N)-carboxy-isoserine

摘要

Medicaments with carcinostatic or immunostimulant activity contain propionic acid derivs. of formula (I): ACH2-CHB-COR.(In (I) R is OH, NH2 or 1-4C alkoxy; one of A and B is NH2 and the other is Cl or OH, or A and B together are NH or N-CO-O gp. Cpds. (I) are precursors of N-carboxy-isoserine (DT 2528451). They have the same pharmacological activity but are more stable. A typical cpd. is aziridine-2-carboxamide. (I) can be administered orally, but are pref. injected in the form of aq. solns. contg. stabilisers solvent aids or weak alkaline buffers.