发明名称 |
Process for the preparation of 14-hydroxymorphinan derivatives |
摘要 |
N-substituted-14-hydroxy-3-substituted-morphinan derivatives have been found to possess potent narcotic agonist or antagonist activity. In particular, the compound 3,14-dihydroxy-N-cyclobutylmethylmorphinan has been found to possess potent agonist/antagonist activity. A new and novel total synthesis for the preparation of these compounds is described herein.
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申请公布号 |
US4017497(A) |
申请公布日期 |
1977.04.12 |
申请号 |
US19750632947 |
申请日期 |
1975.11.18 |
申请人 |
BRISTOL-MYERS COMPANY |
发明人 |
LIM, GARY;HOOPER, JOHN W. |
分类号 |
C07D221/28;C07D317/72;C07D491/10;(IPC1-7):C07D221/28 |
主分类号 |
C07D221/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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