发明名称 |
A METHOD OF ASSESSING PROTEIN MODIFICATION STATUS AND IDENTIFYING BIOMARKERS LINKED TO CELL SIGNALING PATHWAYS |
摘要 |
The present invention provides methods of assessing protein modification status and identifying biomarkers linked to cell signaling pathways. The invention provides a method of creating a dataset of modification sites, comprising grouping modification sites on modified peptides from a first sample which has been treated with a first modulator of a protein modifying enzyme and modification sites on modified peptides from a second sample which has been treated with a second modulator of the same protein modifying enzyme into a single group, according to the effect of said first and second modulators of said protein modifying enzyme on said modification sites, wherein said first and second modulators of said protein modifying enzyme are different. The invention further provides a method of preparing a database, methods of treatment and methods of diagnosis. |
申请公布号 |
WO2016193745(A1) |
申请公布日期 |
2016.12.08 |
申请号 |
WO2016GB51639 |
申请日期 |
2016.06.03 |
申请人 |
QUEEN MARY UNIVERSITY OF LONDON |
发明人 |
CUTILLAS, Pedro Rodriguez;WILKES, Edmund |
分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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