agente terapêutico para melhorar as propriedades da pele compreendendo um derivado de morfinano ou qualquer um de seus sais de adição de ácido farmacologicamente permissíveis como um ingrediente ativo.

摘要

The object of this invention is to provide a novel medicine useful for therapy to improve the skin properties such as skin drying, skin roughening and the skin darkening involved in hyperkeratosis (thickened keratin layer) via a skin moisture retaining effect against the decline of the skin functions brought about by various causes. This invention provides a skin property-improving therapeutic agent comprising a compound having a specific morphinan skeleton typified by a compound 1 represented by the following formula (II) or any of its pharmacologically permissible acid addition salts as an active ingredient.