发明名称 |
DISRUPTION OF THE WAVE3 PROTEIN COMPLEX FOR SUPPRESSION OF INVASION AND METASTASIS |
摘要 |
As disclosed herein, stapled peptides targeting the interaction interface between proteins that maintain the integrity of Wiskott-Aldrich syndrome protein family member 3 (WASF3) leads to destabilization of WASF3 and suppression of invasion. Disclosed are stapled peptides that inhibit the binding of Cytoplasmic FMR1-interacting protein 1 (CYFIP1) to either WASF3 or NCK-associated protein (NCKAP1). Also disclosed are methods for treating or suppressing invasion and metastasis of a cancer in a subject that involve administering to the subject a therapeutically effective amount of a stapled peptide disclosed herein. |
申请公布号 |
WO2016164768(A1) |
申请公布日期 |
2016.10.13 |
申请号 |
WO2016US26713 |
申请日期 |
2016.04.08 |
申请人 |
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. |
发明人 |
KENNEDY, Eileen J. |
分类号 |
A61K38/08;A61P25/18 |
主分类号 |
A61K38/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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