Absorbable, permeability-modulated barrier composites and applications thereof

摘要

Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.

主权项

1. An absorbable, permeability-modulated barrier composite comprising:
at least three physicochemically distinct components; one component comprising a flexible film having a thickness of less than 200 microns, the film comprising a synthetic absorbable polymer, a second component comprising a knitted mesh and a third component comprising an electrostatically spun, non-woven microfibrous fabric, and wherein the flexible film is adjoined directly to the knitted mesh which is adjoined directly to the microfibrous fabric to form a three component layered composite; wherein the knitted mesh comprises an absorbable block copolymer comprising a block derived only from trimethylene carbonate and terminal segments derived from glycolide; and wherein the flexible film is made of a polyaxial copolyester derived from at least two monomers selected from the group consisting of glycolide, l-lactide, ε-caprolactone, trimethylene carbonate, p-dioxanone, 1,5-dioxepan-2-one, and a morpholinedione.