| 摘要 |
NEW MATERIAL:A 16-membered macrolide derivative of formula I (A is II, III, etc.; R is H, acetyl, propionyl, n-butylyl, etc.) and its acid addition salt. EXAMPLE:The compound of formula IV. USE:Remedy for infectious diseases of Gram-positive bacteria or Mycoplasma. The concentration of the compound in blood is higher than that of the starting material. PROCESS:The compound I is prepared by reacting a 16-membered macrolide antibiotic substance V with a cultured medium, cells, or their treated product of microorganisms belonging to actionomycetes (e.g. Streptomyces albireticuli, etc.) in an aqueous medium (a phosphate buffer solution, sodium carbonate buffer solution, etc.) at pH 4-10, in the absence of oxygen (in an atmosphere of inert gas such as nitrogen, argon, etc.) with or without agitation, at 15-45 deg.C, pref. 25-35 deg.C. |
