发明名称 |
Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization |
摘要 |
Presently provided are inhibitors of IDO and TDO and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase and tryptophan 2,3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease. |
申请公布号 |
AU2014241079(B2) |
申请公布日期 |
2016.12.15 |
申请号 |
AU20140241079 |
申请日期 |
2014.03.10 |
申请人 |
Newlink Genetics Corporation |
发明人 |
Kumar, Sanjeev;Waldo, Jesse;Jaipuri, Firoz;Mautino, Mario |
分类号 |
C07D235/02;A61K31/416;A61K31/4188;A61K31/4192;A61K31/4196;A61P37/02;C07D487/04 |
主分类号 |
C07D235/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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