| 摘要 |
This invention relates to new pleuromutilins of the formula: <IMAGE> wherein either R1 is ethyl or vinyl, n is an integer from 2 to 5, X is sulphur, a group <IMAGE> or a group =N-R4I, wherein either Y and Z are both sulphur, or one of Y and Z is oxygen and the other is sulphur, and R4I is hydrogen or a group of the formula: <IMAGE> wherein R1 is as defined above, each of R2 and R3 is alkyl of 1 to 10 carbon atoms, or R2 and R3 together with the nitrogen atom form a heterocycle of 5 to 7 ring members, and pharmaceutically acceptable acid addition salts and quaternary salts thereof. Processes for the preparation of such compounds are described. The compounds are antibiotics with an antibacterial effect.
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