| 主权项 |
1. A composition comprising:
(i) at least one kinase inhibiting peptide incorporated with a nanoparticle, wherein the kinase inhibiting peptide is of Formula I:
Z1-X1-X2-X3-X4 X5-X6-X7-X8-X9-X10-Z2 wherein Z1 and Z2 are independently absent or are transduction domains; X1 is KA; X2 is L; X3 is selected from the group consisting of V, L, I, A, G, Q, N, S, T, and C; X4 is R; X5 is Q; X6 is L; X7 is selected from the group consisting of S, A, C, T, and G; X8 is V; X9 is A; and X10 is A or is absent, wherein the nanoparticle comprises at least one copolymerized monomer having an anionic side chain and at least one additional copolymerized monomer, wherein the at least one copolymerized anionic monomer is 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), wherein the AMPS is effective to increase drug loading and control drug release; (ii) a crosslinker, wherein the crosslinker is selected from the group consisting of N,O dimethacryloylhydroxylamine, divinyl adipate, N,N-Bis(acryloyl)cystamine and N,N′-methylenebisacrylamide; and (iii) a stabilizer that is coupled to the nanoparticle, wherein the stabilizer is effective to reduce aggregation of the nanoparticles to maintain the stability of the nanoparticles. |
