Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof

摘要

Disclosed is a therapeutic formulation suitable for intravenous administration to a subject comprising: an aqueous solution; a hydrophobic active agent; dimyristoylphosphatidyl choline (DMPC); and an opsonization reducer; wherein the hydrophobic active agent is coenzyme Q10; wherein the hydrophobic active agent is dispersed into colloidal nano-dispersion of particles; and wherein the formulation comprises a coenzyme Q10:dimyristoylphosphatidyl choline weight per volume ratio of 4:2 to 4:3.