摘要 |
<p>The novel tetradecapeptides in which Y is L-Cha, L-Leu, or D-Phe are described along with corresponding non-toxic pharmaceutically-acceptable acid addition salts as well as intermediates useful in the synthesis of the tetradecapeptides. These tetradecapeptides are prepared by reacting the corresponding straight-chain tetradecapeptide with an oxidizing agent to convert the two sulfhydryl groups to a disulfide bridge. These tetradecapeptides as well as their pharmaceutically-acceptable acid addition salts inhibit the release of growth hormone. (In the above formula for the novel tetradecapeptides the abbreviation Cha signifies cyclohexylalanine).</p> |