| 摘要 |
PURPOSE:To prepare an anthracycline glycoside antibiotic efficiently and advantageously, by adding a specific aglycone to a medium solution wherein a bacterium producing anthracyline antibiotic is cultivated. CONSTITUTION:To a medium solution comprising a conventional carbon source, nitrogen source, inorganic salt, and a very small amount of necessary element, an aglycone shown by the formula II (e.g., aklavinone) is added as a base, and cultivation is carried out in the presence of a strain or variant belonging to the genus Streptomyces. The cultivation is carried out at 20-40 deg.C aerobically. For example, Streptomyces coeruleorubidus (FERM-P. 3540) is used as the strain or its variant. The cultivation prepares advantageously an anthracycline glycoside (e.g., adriamycine) shown by the formula II. |
